Possible Interaction: Niacin and Antipsychotic Agents

“It is important to consider the interactions between nicotinic and antipsychotic drugs to develop the most efficacious treatment for cognitive improvement in people with schizophrenia.”

“ Nicotinic interactions with antipsychotic drugs , are complex since both nicotine and antipsychotics have complex actions.”

“Thus, it is critical to understand the interaction between nicotinic treatments and antipsychotic drugs.”

“Thus, nicotinic interactions with antipsychotic drugs are widespread.”

“Serotonergic actions of antipsychotic drugs may decrease efficacy of nicotinic co-treatments.”

“Thus it appears that antipsychotic drugs with actions blocking 5HT2 receptors may limit the efficacy of nicotinic co-treatments for cognitive enhancement.”

“However, in schizophrenia the efficacy of nicotinic treatments may be limited by co-treatment with antipsychotic drugs like clozapine.”

“Given that many antipsychotic drugs have substantial 5-HT2 antagonist effects, these atypical antipsychotic drugs may reduce the cognitive improvements caused by nicotinic treatments.”

“Altogether, these results raise the possibility that atypical neuroleptics could derive some of their therapeutic effects not only from their well-known inhibitory action on dopaminergic receptors, but also from their pre- and post-synaptic modulation of nicotinic neurotransmission.”