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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Niacin
drug:
Aminothiadiazole
Research Papers that Mention the Interaction
“Niacinamide evaluated in in vitro test systems did affect development, but Niacinamide reduced the reproductive/developmental toxicity of 2-aminonicotinamide-amino-1,3,4-thiadiazole hydrochloride and urethane.”
Final report of the safety assessment of niacinamide and niacin.“ Nicotinamide , given immediately after aminothiadiazole , was effective in blocking the inhibition.”
The effect of aminothiadiazole on glycogenesis and glycogenolysis in fetal and neonatal rat liver.“Since nicotinamide is known to prevent or reverse the antileukemic activity of aminothiadiazole , it is probable that the inhibition of synthesis of guanosine monophosphate is related to the antileukemic action of this agent.”
“The teratogen 2-amino-1,3,4-thiadiazole ATDA ) is an antagonist of nicotinamide , and may act by interfering with the synthesis or utilization of the coenzyme nicotinamide adenine dinucleotide (NAD).”
“This effect diminished as the interval between ATD and NAM administration lengthened so that by 12 h little protection remained.”
“Both nicotinamide and nicotinic acid blocked the anti-leukemic activity of ATDA in combination with INAM.”
“Isonicotinamide (INAM), 6-aminopicolinamide, and several related nicotinamide analogs have been demonstrated to enhance the activity of 2-amino-1,3,4-thiadiazole ( ATDA ) against transplanted mouse leukemias.”
“Similarly, nicotinic acid reversed the antileukemic activity of ATDA but did not protect against 3-AP toxicity.”
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