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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Niacin and Aminothiadiazole



Research Papers that Mention the Interaction

Niacinamide evaluated in in vitro test systems did affect development, but Niacinamide reduced the reproductive/developmental toxicity of 2-aminonicotinamide-amino-1,3,4-thiadiazole hydrochloride and urethane.
International journal of toxicology  •  2005  |  View Paper
Nicotinamide , given immediately after aminothiadiazole , was effective in blocking the inhibition.
Teratology  •  1983  |  View Paper
Since nicotinamide is known to prevent or reverse the antileukemic activity of aminothiadiazole , it is probable that the inhibition of synthesis of guanosine monophosphate is related to the antileukemic action of this agent.
Cancer research  •  1976  |  View Paper
The teratogen 2-amino-1,3,4-thiadiazole ATDA ) is an antagonist of nicotinamide , and may act by interfering with the synthesis or utilization of the coenzyme nicotinamide adenine dinucleotide (NAD).
Teratology  •  1976  |  View Paper
This effect diminished as the interval between ATD and NAM administration lengthened so that by 12 h little protection remained.
Journal of embryology and experimental morphology  •  1973  |  View Paper
Both nicotinamide and nicotinic acid blocked the anti-leukemic activity of ATDA in combination with INAM.
Isonicotinamide (INAM), 6-aminopicolinamide, and several related nicotinamide analogs have been demonstrated to enhance the activity of 2-amino-1,3,4-thiadiazole ( ATDA ) against transplanted mouse leukemias.
Cancer research  •  1964  |  View Paper
Similarly, nicotinic acid reversed the antileukemic activity of ATDA but did not protect against 3-AP toxicity.
Cancer research  •  1962  |  View Paper