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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Niacin and 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbazone

Research Papers that Mention the Interaction

The results indicate that, starting at 50 mg/kg, nicotinamide can protect animals against most of the neurobehavioral effects of 3-AP.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques  •  1982  |  View Paper
When nicotinamide was given 9 hours prior to 3-AP , protection by the metabolite was reduced.
Cancer research  •  1962  |  View Paper
This finding might be interpreted as evidence that 3-AP , acting as an antivitamin, displaces nicotinamide from its nucleotides or prevents its incorporation therein, or, alternatively, that 3-AP is biologically oxidized to nicotinic acid and is thus, in a sense, a provitamin.
The Journal of biological chemistry  •  1952  |  View Paper