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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“In contrast, the ACTH response to hypoglycemia was significantly higher when L-NAME was administered.”
Influence of nitric oxide on hypoglycemia - or angiotensin II-stimulated ACTH and GH secretion in normal men“ L-NAME only moderately diminished the CRH-induced ACTH secretion, suggesting that a major part of the CRH-induced HPA axis activation is of neuronal origin.”
“ L-NAME significantly lowered the ACTH and corticosterone response to clenbuterol (10 microg i.c.v.),”
Nitric oxide in the adrenergic-and CRH-induced activation of hypothalamic-pituitary-adrenal axis.“ L-NAME (2 mg/kg), a general nitric oxide synthase (NOS) inhibitor, considerably reduced the ACTH and corticosterone response to IL-1beta (0.5 microg/rat) the same extent in control and crowded rats.”
“NO mediated the acute response to ACTH because Nω-nitro-l-arginine methyl ester , a NO synthase inhibitor, and hemoglobin, a NO scavenger, blocked the stimulation of corticosterone release induced by ACTH.”
“On the other hand, L-NAME blunted the effect of shocks on the early phase of ACTH release, while we had reported earlier that metalloporphyrins exerted a similar effect.”
“Intracerebroventricular administration of N-ω-nitro-L-arginine methyl ester L-NAME ), a general NOS inhibitor, significantly enhanced ACTH and CS responses to this stress but did not change the basal levels of these hormones.”
“Collectively, these … injection of L-NAME very quickly augments …-inflammatory cytokines on ACTH secretion, and does so for at least 4 h. Other arginine derivatives known to block the activity of … as L-NMMA and L-NNA, exert an effect that is virtually identical to that of L-NAME.”
“To test the hypothesis that L-NAME might alter ACTH secretion at least in part by modifying the secretion of pro-inflammatory cytokines, we measured plasma concentrations of TNF-alpha and IL-6 following endotoxin injection in the presence or absence of L-NAME.”
“We … whether NG-nitro-L-arginine methyl ester (L-NAME), a specific inhibitor of nitric oxide synthase (NOS), can modify the stress-induced adrenocorticotropic hormone (ACTH) and corticosterone responses, because we found that immobilization-induced stress increases NOS mRNA and protein levels and enzyme activity in the adrenal cortex.”
“In contrast, the nitric oxide synthase inhibitor, Nw-nitro-L-arginine methyl ester (30 mg/kg, iv), produced a significant enhancement of the ACTH response within 30 min of its injection.”
“It was found that L-NAME significantly enhanced plasma ACTH concentrations.”
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