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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nevirapine
supplement:
St John's Wort
Research Papers that Mention the Interaction
“Well-documented SJW interactions include (1) reduced blood cyclosporin concentration, as suggested by multiple case reports as well as by … lethargy when SJW was given with serotonin reuptake inhibitors, (3) unwanted pregnancies in women while using oral contraceptives and SJW , and (4) reduced … (e.g., indinavir, nevirapine ) and …) drugs.”
Herb–Drug Interactions with St John’s Wort (Hypericum perforatum): an Update on Clinical Observations“ St John's wort also enhances the metabolism of other CYP3A4 substrates including the protease inhibitors indinavir and nevirapine , oral contraceptives, and tricyclic antidepressants such as amitriptyline.”
“Case reports or case series suggest interactions of St John’s wort with adrenergic vasopressors, anaesthetics, bupropion, buspirone, ciclosporin, eletriptan, loperamide, nefazodone, nevirapine , oral contraceptives, paroxetine, phenprocoumon, prednisone, sertraline, tacrolimus, theophylline, tibolone, tryptophan, venlafaxine and warfarin.”
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