Possible Interaction: Neuropeptide Y and Progesterone

“Elevated circulating progesterone concentration up-regulated NPY and down-regulated CART genes expression in hypothalamus of females.”

“ NPY reversed the progesterone blockade of estradiol-induced Y1R and MOR internalization in the arcuate nucleus and MPN, respectively.”

“In D2, NPY , VIP or SP, both alone and with norepinephrine, increased Po release.”

“In the CG-SON-O system, in D1, the addition of NPY and VIP alone increased Po release, while SP decreased it.”

“Thus, we determined whether NPY cells possess progesterone receptors (PR) and whether progesterone treatment up‐regulates NPY mRNA expression in the arcuate nucleus.”

“ Progesterone alone had a stimulatory effect on NPY mRNA in the MBH and HIPP.”

“We have reported earlier that sequential treatment of ovariectomized (ovx) rats with estrogen and progesterone to stimulate a preovulatory-type LH surge elevated the levels of both NPY and preproNPY mRNA levels in the hypothalamus concomitant with dynamic changes in LHRH activity.”

“The data indicate that progesterone modulates hypothalamic NPY mRNA and anterior pituitary NPY levels as well as GnRH mRNA levels and that modulation of NPY levels in the hypothalamic-pituitary axis occurs prior to modulation of GnRH gene expression.”

“Progesterone treatment 24 hr after estrogen induced an increase in LHRH release followed by an LH surge: Progesterone increased the pulse frequencies of both NPY release and LHRH release, maintaining the tight coupling of the pulses, while increasing LHRH pulse amplitude, but not NPY pulse amplitude.”

“In the MDS, a 30-min perfusion with NPY , SP or VIP (10 nmol/l, 100 nmol/l and 1 mumol/l) induced significant acute effects on progesterone and oxytocin release.(ABSTRACT TRUNCATED AT 250 WORDS)”

“However, injection of 1 or 2 mg of progesterone into animals receiving the high physiological dose of estrogen slightly, although not significantly, reduced NPY (10 microM)-stimulated LHRH secretion.”

“Treatment with the pharmacological dose of progesterone (19 mg) significantly decreased the ability of NPY to stimulate LHRH release when compared to vehicle-injected controls or to animals receiving 1 mg of progesterone.”

“We have investigated the hypothesis that administration of progesterone to estrogen-treated ovariectomized (OVX) rats enhances the stimulatory effects of neuropeptide Y (NPY) on the secretion of luteinizing hormone-releasing hormone (LHRH) from median eminence (ME) fragments in vitro.”