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Discover Supplement-Drug Interactions

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Last Updated: a month ago

Possible Interaction: Neuromuscular Depolarizing Agents and Tubocurarine

Research Papers that Mention the Interaction

They were postulated to explain why the administration of depolarizing agents or anti-cholinesterases cause fasciculations, a sure sign of nerve reaction to the drug, that can be prevented by prior administration of tubocurarine or other nondepolarizing relaxants.
Acta anaesthesiologica Scandinavica  •  1994  |  View Paper
d-Tubocurarine blocked the depolarizing action of pyrantel but not levamisole on rat-isolated hemidiaphragm.
Toxicology and applied pharmacology  •  1992  |  View Paper
d-Tubocurarine (0.02-0.2 mmol/l), hexamethonium (0.5-5.0 mmol/l) and atropine (0.1 mmol/l) blocked the depolarizing and hyperpolarizing ACh responses.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology  •  1985  |  View Paper