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“The inhibitor effects of quinidine were significantly enhanced (P < 0.05) when the preparations were preincubated in 40 mm KCl ( depolarizing ) solution.”
British journal of pharmacology • 1994 | View Paper
“Even after removal of the fast inactivation process of …-dependent block was observed in the presence of quinidine when various depolarizing pulse durations (5 ms approximately 200 ms) … repetitively at intervals of 300 ms approximately 2 s. Longer depolarizing pulses and higher frequency pulse … produced greater use-dependent block.”
Journal of molecular and cellular cardiology • 1991 | View Paper
“ Depolarizing pulses elicited slowly inactivating whole-cell K+ currents, which were blocked by external application of tetraethylammonium+, 4-aminopyridine, and quinidine.”