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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Neuromuscular Depolarizing Agents and Quinidine

Research Papers that Mention the Interaction

The inhibitor effects of quinidine were significantly enhanced (P < 0.05) when the preparations were preincubated in 40 mm KCl ( depolarizing ) solution.
British journal of pharmacology  •  1994  |  View Paper
Even after removal of the fast inactivation process of …-dependent block was observed in the presence of quinidine when various depolarizing pulse durations (5 ms approximately 200 ms) … repetitively at intervals of 300 ms approximately 2 s. Longer depolarizing pulses and higher frequency pulse … produced greater use-dependent block.
Journal of molecular and cellular cardiology  •  1991  |  View Paper
Depolarizing pulses elicited slowly inactivating whole-cell K+ currents, which were blocked by external application of tetraethylammonium+, 4-aminopyridine, and quinidine.
The Journal of general physiology  •  1988  |  View Paper