Possible Interaction: Neuromuscular Depolarizing Agents and Potassium

“Both distribution across cell membranes and/or renal excretion of potassium may be altered by pharmacologic agents such as diuretics, alpha- and beta-catechol antagonists and agonists, depolarizing agents , and digitalis.”

“The analysis showed that neuronal complexity increased when cells were incubated with a depolarizing potassium concentration and there was a correlation with an increase in fractal dimension (D5 mM KCl = 1.08 +/- 0.01, D25 mM KCl =1.25 +/- 0.01).”

“ K m Pi increased with depolarizing voltage and was more sensitive to voltage at reduced Na+.”

“ Depolarizing concentrations of potassium inhibited spontaneous contractions in both RMo cultures and primary chick myotube cultures.”

“ Depolarizing concentrations of potassium significantly stimulated tMgrp release.”

“In the presence of depolarizing potassium concentrations, there was a reduced level of GABA efflux in hippocampal and cortical slices, and a marked reduction in the release of glutamate in cortical slices from B-6 restricted rats.”

“ Depolarizing concentrations of potassium in the presence of calcium stimulated significant increments in release of IR-ACTH/IR-beta-endorphin by amygdala (111/105%) and cortical (162/136%) cells.”

“Hypothalamic tissue spontaneously released IR-PRL, and this release was increased by depolarizing concentrations of potassium by a calcium-dependent mechanism.”

“All of the test substances examined, except n-pentane and n-hexane, shifted the voltage dependence of the potassium steady-state activation in the depolarizing direction.”

“The presence of depolarizing concentrations of potassium (25–55 mM) resulted in significant increases in catecholamine synthesis in both tissue preparations.”