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Last Updated: 3 years ago

Possible Interaction: Neuromuscular Depolarizing Agents and Cobaltous Cation

Research Papers that Mention the Interaction

This behavior, which was more pronounced when larger pulses of depolarizing current were injected (and thus when repetitive firing attained higher rates), was markedly decreased by Co2+ application.
Hippocampus  •  2001  |  View Paper
Activation of cells by kainate, but not by depolarizing stimuli, stimulated the uptake of Co2+.
The Journal of neuroscience : the official journal of the Society for Neuroscience  •  1994  |  View Paper
There was a 5‐10% decrease in the rate of rise of the inward current The principal effect of Co2+ and Ni2+ current density seems to be a decrease in the rate at which the inward currents decline during a depolarizing voltage pulse.
Journal of neuroscience research  •  1991  |  View Paper
In contrast, the inorganic Ca2+ channel blocker, Co2+ , inhibited secretion equally well under polarizing or depolarizing conditions.
European journal of pharmacology  •  1991  |  View Paper
The inorganic VSCC blockers Co2+ and Cd2+ blocked 45Ca2+ uptake into these cells in both 5 mM K+ and 50 mM K+ ( depolarizing ) conditions.
Biochemical and biophysical research communications  •  1985  |  View Paper
In differentiated cells, with one or several processes, an early inactivating inward current approximately equal to 50 microA/cm2 was observed in response to depolarizing steps from the holding potential -60 to -70 mV, which was insensitive to 2 microM tetrodotoxin but readily blocked by Co2+ (6 mM).
Neuroscience Letters  •  1985  |  View Paper