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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Nerve Growth Factor
supplement:
Zinc Cation
Research Papers that Mention the Interaction
“It has recently been shown that transition metal cations Zn2+ and Cu2+ bind to histidine residues of nerve growth factor (NGF) and other neurotrophins (a family of proteins important for neuronal survival) leading to their inactivation.”
The binding of zinc and copper ions to nerve growth factor is differentially affected by pH: implications for cerebral acidosis“We have previously provided evidence that two transition metal cations, Zn2+ and Cu2+, can alter the conformation of nerve growth factor (NGF), rendering it unable to bind to its receptors or to activate signal transduction pathways.”
Zinc and Copper inhibit nerve growth factor-mediated protection from oxidative stress-induced apoptosis
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