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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nerve Growth Factor
supplement:
Tyrosine
Research Papers that Mention the Interaction
“ Nerve growth factor enhanced tyrosine phosphorylation of TCGAP through activation of Src family kinases.”
“By isolating nuclei of PC12 cells and immunoprecipitating aPKC with Ab-PY256, we observed that Tyr256 is rapidly phosphorylated upon NGF treatment prior to entry of aPKC into the nucleus.”
“ NGF , but not IGF-I, stimulates tyrosine phosphorylation and activation of PLC-γ1 which can be inhibited in a dose-dependent manner by phosphoinositide-specific phospholipase C (PI-PLC) inhibitor U73122 (IC50=4 μM).”
“Indeed, NGF induced tyrosine phosphorylation and stimulated kinase activity of p185 HER2 , a kinase receptor of the HER family.”
“We also show that NGF induces tyrosine phosphorylation of Shc and its association with Grb2.”
Activation of Vav and Ras through the nerve growth factor and B cell receptors by different kinases.“While the tyrosine phosphorylation of TrkA, SHC and PLC-gamma 1 increased with time in the presence of NGF and was inhibited by the tyrosine kinase inhibitor K252a, the state of tyrosine phosphorylation of c-Crk-II did not appear to change with NGF treatment.”
“Analysis of specific gp140trk immunoprecipitates indicated that addition of NGF to B cells induced a rapid increase in the tyrosine phosphorylation of gp140trk and inhibition of this phosphorylation prevented the tyrosine phosphorylation of other proteins.”
“ NGF caused both concentration‐ and time‐dependent increases in tyrosine phosphorylation of five proteins of 140, 110, 85, 60 and 42 kDa, which were identified as phospholipase C‐γ1, phosphatidylinositol‐3 kinase and mitogen‐activated protein kinase.”
“Stimulation of three different human B-lymphoblastoid cell lines with NGF induced the tyrosine phosphorylation and activation of the p42erk-2 isoform of MAP-kinase (MAPK).”
“On the other hand, chronic administration of l-tyrosine increased NGF levels in posterior cortex.”
“Our findings showed that acute administration of l-tyrosine decreased NGF levels in striatum of 10-day-old rats.”
Effect of Acute and Chronic Administration of l-Tyrosine on Nerve Growth Factor Levels in Rat Brain“We find that NGF induces tyrosine phosphorylation of APP, and that APP interacts with TrkA and this interaction requires Y682.”
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