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Last Updated: 6 months ago

Possible Interaction: Nerve Growth Factor and Tyrosine

Research Papers that Mention the Interaction

Nerve growth factor enhanced tyrosine phosphorylation of TCGAP through activation of Src family kinases.
Journal of Biological Chemistry  •  2006  |  View Paper
By isolating nuclei of PC12 cells and immunoprecipitating aPKC with Ab-PY256, we observed that Tyr256 is rapidly phosphorylated upon NGF treatment prior to entry of aPKC into the nucleus.
Journal of cellular biochemistry  •  2002  |  View Paper
NGF , but not IGF-I, stimulates tyrosine phosphorylation and activation of PLC-γ1 which can be inhibited in a dose-dependent manner by phosphoinositide-specific phospholipase C (PI-PLC) inhibitor U73122 (IC50=4 μM).
Oncogene  •  1999  |  View Paper
Indeed, NGF induced tyrosine phosphorylation and stimulated kinase activity of p185 HER2 , a kinase receptor of the HER family.
The Journal of Biological Chemistry  •  2000  |  View Paper
We also show that NGF induces tyrosine phosphorylation of Shc and its association with Grb2.
Cellular immunology  •  1999  |  View Paper
While the tyrosine phosphorylation of TrkA, SHC and PLC-gamma 1 increased with time in the presence of NGF and was inhibited by the tyrosine kinase inhibitor K252a, the state of tyrosine phosphorylation of c-Crk-II did not appear to change with NGF treatment.
Oncogene  •  1996  |  View Paper
Analysis of specific gp140trk immunoprecipitates indicated that addition of NGF to B cells induced a rapid increase in the tyrosine phosphorylation of gp140trk and inhibition of this phosphorylation prevented the tyrosine phosphorylation of other proteins.
NGF caused both concentration‐ and time‐dependent increases in tyrosine phosphorylation of five proteins of 140, 110, 85, 60 and 42 kDa, which were identified as phospholipase C‐γ1, phosphatidylinositol‐3 kinase and mitogen‐activated protein kinase.
European journal of immunology  •  1996  |  View Paper
Stimulation of three different human B-lymphoblastoid cell lines with NGF induced the tyrosine phosphorylation and activation of the p42erk-2 isoform of MAP-kinase (MAPK).
Journal of immunology  •  1995  |  View Paper
On the other hand, chronic administration of l-tyrosine increased NGF levels in posterior cortex.
Our findings showed that acute administration of l-tyrosine decreased NGF levels in striatum of 10-day-old rats.
Neurochemical Research  •  2013  |  View Paper
We find that NGF induces tyrosine phosphorylation of APP, and that APP interacts with TrkA and this interaction requires Y682.
The Journal of Neuroscience  •  2011  |  View Paper
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