Possible Interaction: Nerve Growth Factor and Tretinoin

“Both NGF and BDNF had only a modest synergistic effect when given after ATRA treatment.”

“In addition, the effect on NB proliferation was investigated when ATRA was combined with a 7-day treatment with NGF or BDNF (10, 50, 100 ng/mL) either before or after the 7-day ATRA treatment.”

“In the present study, we have investigated whether NGF and RA may interact to control the proliferation of SCLC cell lines.”

“In conclusion, NGF and retinoic acid in combination inhibit proliferation and invasion of thyroid papillary carcinoma cells.”

“We found that NGF and retinoic acid do not affect cell proliferation on their own but in combination they produce a strong inhibition.”

“In vitro data have shown that retinoic acid up regulates LNGFR expression and NGF sensitivity via interaction with specific regulatory elements in the LNGFR gene promoter.”

“Imaging studies of gfp‐tagged NGFI‐… confirmed that mitochondrial translocation of NGFI‐B occurred following treatment with CaI … was reduced by addition of 9‐cis‐retinoic acid (1 μM), a retinoid X receptor (RXR) agonist that prevents dimerization … RXR and NGFI‐B that is known to occur before translocation.”

“All-trans retinoic acid ATRA ) promotes the endogenous expression of both nerve growth factor (NGF) and retinoic acid receptor beta (RAR-β).”

“These data suggest that the combined use of NGF and retinoic acid , or mimicking drugs, may provide the basics for the development of novel strategies in the therapeutic management of neuroblastomas.”

“ Retinoic acid (RA) promotes the endogenous expression of nerve growth factor and its receptor.”

“The phorbol ester (12-O-tetradecanoylphorbol-13-acetate) and cAMP poorly induced promoter activity; retinoic acid decreased it by 50%, whereas nerve growth factor and dexamethasone had no effect.”

“In this study we show that NGF increases RARβ protein levels by enhancing basal RARβ2 promoter activity, and potentiates stimulation by RA in transient transfection assays.”