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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nerve Growth Factor
supplement:
Genistein
Research Papers that Mention the Interaction
“ Genistein , an inhibitor of tyrosine protein kinase, completely inhibited NGF induced PAI-1 mRNA in the presence of 100 μM. Wortmannin, a potent and specific inhibitor of phosphatidylinositol 3-kinase (PI-3 kinase), decreased induction of PAI-1 mRNA level at doses of ≥ 10-7 M.”
Expression of nerve growth factor‐induced type 1 plasminogen activator inhibitor (PAI‐1) mRNA is inhibited by genistein and wortmannin“Both effects of NGF were blocked by genistein , consistent with the involvement of tyrosine kinase pathways.”
“Inhibition of the NGF receptor-linked protein tyrosine kinase by either genistein or K252a attenuated the acidification rate response to NGF.”
“Pretreatment of cells with selective inhibitors of tyrosine kinase (ST638 and genistein ) and phospholipases C (neomycin B) and A2 (p-Bromophenacyl bromide; BPB and indomethacin) depress neurite outgrowth following 60 min treatment with NGF (0.1 microgram/ml).”
“ Genistein , a protein tyrosine kinase inhibitor, blocked nerve growth factor‐mediated neurite extension as well as diminished activation of pp42/44MAP kinase.”
“Both effects of NGF were blocked by genistein , consistent with the involvement of tyrosine kinase pathways.”
Nerve growth factor regulates[Formula: see text] absorption in thick ascending limb: modifying effects of vasopressin.
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