“The muscarinic activities of ACh and (+)- trans -ACTM on dog blood pressure were markedly potentiated by neostigmine (41-fold and 23-fold, respectively), but that of (-)- trans -ACTM was poorly potentiated (3-fold).”
“These results indicate that the biologic activity of (+)- trans -ACTM is potentiated by neostigmine more than that of (-)- trans -ACTM because the former is a better substitute for the cholinesterases.”