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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Neomycin
supplement:
Tubocurarine
Research Papers that Mention the Interaction
“On tension recordings, an in vitro addition of d-tubocurarine inhibited the twitch tensions evoked by the nerve stimulations in both cases of saline or neomycin treatment.”
“These results suggest that repeated treatments with neomycin enhance the inhibitory effect of d-tubocurarine on the neuromuscular transmission in mice without eliciting motor incoordination and muscle relaxation.”
Effect of repeated administrations of neomycin on the neuromuscular functions and the enhancement of d-tubocurarine action in mice.“Tubocurarine exhibited no cumulative effects at intervals of 2 h and did not significantly … tension to neomycin after an interval of 2 h. It is concluded that neomycin … tubocurarine despite apparently normal responses to indirect stimulation and that the … alone may explain apnoea reported in patients with the antibiotic.”
“When both d-Tc and neomycin or polymyxin B were added the increase of the NM effect of lidocaine was even greater (p < 0.001).”
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