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“ Neomycin , an aminoglycoside which binds phosphoinositides, inhibits the potassium‐induced release in cortical slices with an IC50 = 0.5 ± 0.07 mM and with IC50 = 0.2 ± 0.03 mM in synaptosomes.”
“Contractile responses to high potassium (80 mM) were inhibited by prior exposure to neomycin to a greater extent than were responses obtained with submaximal equipotent concentrations of the other vasoactive agents.”
The Journal of pharmacology and experimental therapeutics • 1974 | View Paper
“ Neomycine reduces the amount of transmitter released from the motor nerve in response to a nerve volley or to a high external potassium concentration.”