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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Neomycin
supplement:
Phosphatidylinositol 4,5-Diphosphate
Research Papers that Mention the Interaction
“Ca2+ or neomycin usually increased or had little effect on32P incorporation into PA and PIP2.”
Polyphosphoinositides and the shape of mammalian erythrocytes“ Neomycin , an aminoglycoside antibiotic that interacts with polyphosphoinositides, inhibited the breakdown of both phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate , with the latter process being appreciably more sensitive to the drug.”
“These effects correlated with a dramatic decrease in PIP2 affinity, as assessed by PIP2‐induced channel reactivation and inhibition by neomycin , an antagonist of PIP2 binding.”
“However, it was markedly reduced by neomycin and accompanied by an increase in phosphatidylinositol 4,5-bisphosphate (PtdInsP2) synthesis.”
“On the other hand, neomycin , which binds to PtdIns(4,5)P2 , inhibited basal and GTP[S]-stimulated PLD activities.”
“This conclusion is supported by the fact that neomycin , a high affinity ligand of PtdIns-4,5-P2 , also blocked PLD activation.”
“Between 1 and 5 mM of neomycin the initial thrombin-induced decrease in [32P]phosphatidylinositol-4,5-bis-phosphate and production of [32P]phosphatidic acid were gradually inhibited.”
“Therefore, neomycin , a polycation that has been shown to block electrostatic interactions of PIP2 , was intracellularly dialyzed in superior cervical ganglion (SCG) neurons of the rat.”
Maintenance of CaV2.2 channel-current by PIP2 unveiled by neomycin in sympathetic neurons of the rat.“ PIP2 sequestration with neomycin (500 muM) blocked both endothelin- (43 +/- 6%, P < 0.001) and phenylephrine (36 +/- 4%, P < 0.001)-mediated recovery.”
“ Neomycin (100 microM), an antagonist of phosphatidylinositol 4,5-bisphosphate (PIP(2)), blocked SP-induced calcium entry.”
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