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Possible Interaction: Neomycin and Phosphatidylinositol 4,5-Diphosphate

Research Papers that Mention the Interaction

Ca2+ or neomycin usually increased or had little effect on32P incorporation into PA and PIP2.
Lipids  •  2006  |  View Paper
Neomycin , an aminoglycoside antibiotic that interacts with polyphosphoinositides, inhibited the breakdown of both phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate , with the latter process being appreciably more sensitive to the drug.
The Biochemical journal  •  1981  |  View Paper
These effects correlated with a dramatic decrease in PIP2 affinity, as assessed by PIP2‐induced channel reactivation and inhibition by neomycin , an antagonist of PIP2 binding.
The Journal of physiology  •  2006  |  View Paper
However, it was markedly reduced by neomycin and accompanied by an increase in phosphatidylinositol 4,5-bisphosphate (PtdInsP2) synthesis.
Biochimica et biophysica acta  •  1998  |  View Paper
On the other hand, neomycin , which binds to PtdIns(4,5)P2 , inhibited basal and GTP[S]-stimulated PLD activities.
European journal of biochemistry  •  1996  |  View Paper
This conclusion is supported by the fact that neomycin , a high affinity ligand of PtdIns-4,5-P2 , also blocked PLD activation.
The Journal of Biological Chemistry  •  1995  |  View Paper
Between 1 and 5 mM of neomycin the initial thrombin-induced decrease in [32P]phosphatidylinositol-4,5-bis-phosphate and production of [32P]phosphatidic acid were gradually inhibited.
Biochemical and biophysical research communications  •  1987  |  View Paper
Therefore, neomycin , a polycation that has been shown to block electrostatic interactions of PIP2 , was intracellularly dialyzed in superior cervical ganglion (SCG) neurons of the rat.
Archives of biochemistry and biophysics  •  2020  |  View Paper
PIP2 sequestration with neomycin (500 muM) blocked both endothelin- (43 +/- 6%, P < 0.001) and phenylephrine (36 +/- 4%, P < 0.001)-mediated recovery.
American journal of physiology. Cell physiology  •  2009  |  View Paper
Neomycin (100 microM), an antagonist of phosphatidylinositol 4,5-bisphosphate (PIP(2)), blocked SP-induced calcium entry.
Neuroscience Letters  •  2000  |  View Paper
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