Possible Interaction: Natriuretic Peptide, Brain and Adrenocorticotropic Hormone

“We demonstrated that a novel natriuretic hormone, brain natriuretic peptide , modestly inhibited the production of cortisol and aldosterone stimulated by ACTH in cultured bovine adrenocortical cells.”

“However, ANP and VNP, but not BNP and three CNPs, enhanced the steroidogenic action of ACTH in SW interrenal preparations, while CNP1 and CNP4, but not ANP, BNP, VNP and CNP3, potentiated the ACTH action in FW preparations.”

“Results: Graded concentrations of ANP, BNP , or CNP (10–10, 10–9, and 10–8 mol/l) induced a log dose dependent inhibition of ACTH secretion induced by rat corticotropin-releasing factor (10–10 mol/l).”

“In addition, ASIF and BNP-32 , which are the proven ACTH receptor antagonists, reduced the cortisol-stimulatory effect of ACTH and VIP.”

“Overall, the findings clearly demonstrated that ASIF and BNP suppressed the adrenocortical function and inhibited ACTH for their antagonistic action against ACTH primarily at the ACTH receptor site.”

“Stimulation of aldosterone production mediated by adrenocorticotropin was only partially inhibited by atrial and brain natriuretic peptide , while baseline aldosterone was not affected.”