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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Although human MDR1-mediated talinolol transport was not inhibited by 2000 μM naringin, naringin inhibited human OATP1A2-, rat Oatp1a5-, and rat Mdr1a-mediated talinolol transport with IC50 values of 343, 12.7, and 604 μM, respectively, in LLC-PK1 cell and Xenopus laevis oocyte systems.”
Species Difference in the Effect of Grapefruit Juice on Intestinal Absorption of Talinolol between Human and Rat“Six of the investigated flavonoids reduced the secretory flux of talinolol across Caco-2 cells (IC50-values: hesperetin<quercetin<kaempferol<<spiraeoside<isoquercitrin< naringin).”
“The permeability of TLN in rat ileum in the presence of NRG was significantly increased to 3.16×10(-5) cm/s as compare to control value 2.48×10(-5) cm/s.”
“The temperature stability of prepared amorphous forms may be attributed to strong intermolecular hydrogen bond interaction between TLN and NRG , which was confirmed by Gordon-Taylor calculations and FTIR data.”
Simultaneous improvement of solubility and permeability by fabricating binary glassy materials of Talinolol with Naringin: Solid state characterization, in-vivo in-situ evaluation.“ Naringin inhibited talinolol uptake by Oatp1a5 (IC50 = 12.7 μM).”
“The reported IC50 value of naringin for P-gp-mediated transport of talinolol is approximately 2,000 μM. Rat intestinal permeability of talinolol was significantly decreased in the presence of 200 μM naringin, but was significantly increased by 2,000 μM naringin.”
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