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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Naringin
drug:
Pravastatin
Research Papers that Mention the Interaction
“Significance: The combination of naringin and pravastatin did not appear to be better than monotherapy on lipids, but its use could generate euglycemic and antiobesogenic effects, in addition to diminishing the adverse hepatic effects of pravastatin in rats.”
Combination effect naringin and pravastatin in lipid profile and glucose in obese rats“ Naringin inhibited Oatp1a5- and Oatp2b1-mediated uptake of pravastatin and Oatp1a5-mediated, but not Oatp2b1-mediated, uptake of pitavastatin.”
“The plasma concentration of pravastatin after oral administration was significantly decreased by GFJ and naringin , whereas that of pitavastatin was significantly increased.”
“ Naringin , a potent inhibitor of Oatps and Mdr1, decreased the Oatp1a5-mediated uptake of pravastatin with IC50 value of 30.4 μM. Rat intestinal permeability of pravastatin was significantly reduced in the presence of 1,000 μM naringin.”
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