Possible Interaction: Naringin and Paclitaxel

“ Paclitaxel co-… with Naringin synergistically improved its intracellular uptake and 65% in vitro cytotoxicity against breast cancer cells was achieved at its lower dose of 15 µg/…. Results suggest that co-encapsulation of Paclitaxel with Naringin in mixed micelles is an effective strategy for achieving its higher anticancer activity.”

“After intravenous administration of paclitaxel , the AUC was significantly greater (40.8% and 49.1% for naringin doses of 3.3 and 10 mg/kg, respectively), and Cl was significantly slower (29.0% and 33.0% decrease, respectively) than controls.”

“ Oral naringin (3.3 and 10 mg/kg) was pretreated 30 min before intravenous (3 mg/kg) administration of paclitaxel.”

“The significantly greater AUC could be due mainly to an inhibition of metabolism of paclitaxel via CYP3A1/2 by oral naringin.”

“Absorption rate constant (K(a)) of paclitaxel with naringin increased, but not significantly.”

“The AUC of paclitaxel after coadministration of prodrug with naringin to rats was significantly (p<0.05) higher than the prodrug control.”

“The absolute bioavailability (AB, %) of paclitaxel after coadministration of prodrug with naringin increased significantly (p<0.05) from 6.6 to 9.0% and 11.2%.”

“The absolute bioavailability (AB, %) of paclitaxel with naringin was significantly higher (3.5-6.8%, p<0.01) than the control (2.2%).”

“The bioavailability of paclitaxel coadministered as a prodrug with or without naringin was remarkably higher than the control.”

“The plasma concentrations of paclitaxel coadministered with naringin increased significantly (p<0.01 at paclitaxel, p<0.05 at prodrug) compared to the control.”

“The relative bioavailability (RB, %) of paclitaxel after coadministration of prodrug with naringin was 1.35-1.69-fold higher than prodrug control.”

“Conclusion In conclusion, naringin acts as a chemosensitizer which synergistically strengths the cytotoxic effect of paclitaxel in PCa cells.”

“The combination of naringin and paclitaxel treatments synergistically increased the cytotoxic effects of paclitaxel in androgen-independent DU145 and PC3 cells, as well as in androgen-sensitive LNCaP cells.”