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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Naringin and Fexofenadine

supplement:

Naringin

Research Papers that Mention the Interaction

The uptake of [14C]aliskiren and [3H]fexofenadine was linear in OATP1A2-expressing cells and was reduced by naringin , with IC50 values of 75.5 ± 11.6 and 24.2 ± 2.0 μM, respectively.
European Journal of Clinical Pharmacology  •  2011  |  View Paper
The results showed that both paroxetine and naringin greatly inhibited absorption of glyburide and fexofenadine.
Drug metabolism and pharmacokinetics  •  2015  |  View Paper
Naringin most probably directly inhibited enteric OATP1A2 to decrease oral fexofenadine bioavailability.
Clinical pharmacology and therapeutics  •  2007  |  View Paper