supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Naringin
drug:
Fexofenadine
Research Papers that Mention the Interaction
“The uptake of [14C]aliskiren and [3H]fexofenadine was linear in OATP1A2-expressing cells and was reduced by naringin , with IC50 values of 75.5 ± 11.6 and 24.2 ± 2.0 μM, respectively.”
Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects“The results showed that both paroxetine and naringin greatly inhibited absorption of glyburide and fexofenadine.”
“ Naringin most probably directly inhibited enteric OATP1A2 to decrease oral fexofenadine bioavailability.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback