“Our results demonstrated that naringenin could significantly affect the pharmacokinetics of ibrutinib , including prolonging its half-life, increase the area under the concentration-time curve and reducing its clearance time.”
“This study indicated that there is potential for drug-drug interactions between naringenin and ibrutinib , and coadministration of ibrutinib with naringenin or naringenin-containing herbal medicines should be avoided in the clinic.”