Possible Interaction: Naringenin and Doxorubicin Hydrochloride

“The use of naringenin and metformin together with doxorubicin , have shown a significant increase in cytotoxicity when compared with the same concentration of doxorubicin alone in MDA-MB-231 cells and 4T1 cells in vitro.”

“Hesperidin and naringenin increased cytotoxicitity of doxorubicin on MCF-7 cells and HeLa cells.”

“In contrast to doxorubicin alone, doxorubicin in combination with naringenin enhanced antitumor activity in vivo with low systemic toxicity.”

“ResultsThe IC50 values of doxorubicin in combination with naringenin in A549 and MCF-7 cells were approximately 2-fold lower than that of doxorubicin alone.”

“As compared with …, the addition of naringenin … doxorubicin for 1 hour, the levels of reactive oxygen species (ROS) and lipid peroxidation (MDA) obviously decreased, the activity of superoxide dismutase (…) and glutathione peroxidase (GSH-Px) obviously increased in the polymorphonuclear leukocytes, but these were not changed obviously in K562 cells.”

“In addition, NG significantly increased P-glycoprotein level in testes of rats received CP and DX.”

“It was concluded that NG impeded gonadotoxicity of CP and DX in male rats by mitigating oxidative stress, nitrosative stress, inflammation, and apoptosis.”

“Moreover, NG significantly decreased the testicular histopathological injury, and immunohistochemical expression of inducible nitric oxide synthase induced by CP and DX in rat testes.”

“ NG significantly prevented the decreases of serum testosterone and inhibin B in rats received CP and DX.”

“This study investigated the potential ability of NG to block gonadotoxicity induced CP and DX in male rats.”

“Thus, supplementation of NAR may be beneficial in reducing DOX toxicity.”

“Likewise, naringenin and metformin with doxorubicin showed a significant reduction of tumor volume and tumor weight (p < 0.01) in 4T1-induced orthotopic mouse model as compared to the same dose of doxorubicin alone, suggesting combination treatment enhanced antitumor activity in vivo.”

“These results demonstrate that naringenin and metformin enhanced the antitumor effect of doxorubicin in animal models of breast carcinoma, and therefore can be useful as an adjunct treatment with doxorubicin to increase its effectiveness at the lower dose level for the treatment of cancer.”

“ Naringenin similarly diminished expression of Cox-2 and levels of NF-κB and other inflammatory molecules induced by the Dox treatment.”

“In PMNs … which naringenin (50~80 μmol/l) was added 1 h subsequent to ADM , the cell damage induced by ADM was significantly reduced, coincident with reductions in the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) and increases in the activity of superoxide dismutase and glutathione peroxidase.”