Possible Interaction: Naproxen and Tryptophan

“The inhibitory activity of rapid, reversible COX inhibitors (ibuprofen, naproxen , mefenamic acid, and lumiracoxib) demonstrated a significant increase in potency and time dependence of inhibition against double tryptophan murine COX-2 mutants at the 89/90 and 89/119 positions.”

“Moreover, naproxen stimulated the decomposition of tryptophan into kynurenate, which inhibits fibroblast growth factor-1 and delays ulcer healing.”

“Addition of cysteine, tryptophan , and tyrosine induced the significant suppression of NX photodegradation after UV irradiation for 3 h (residual amount of NX; 15.35%, 6.82%, and 15.64%, respectively).”