Possible Interaction: Naltrexone and Adrenocorticotropic Hormone

“ Naltrexone also resulted in higher levels of adrenocorticotropic hormone and cortisol than placebo treatment, and levels of cortisol were negatively correlated with intensity of alcohol craving.”

“ Naltrexone , a relatively pure opiate antagonist, appears to have significant effects on the secretion of the gonadotropins (luteinizing hormone and follicle-stimulating hormone), adrenocorticotropin (ACTH), cortisol, and probably catecholamines.”

“ ACTH level changes as a response to naltrexone in the patients were lower than that in the controls.”

“RESULTS Na trexone ad ministration resulted in a significant ACT H re sponse in the patients while cortisol and ACTH responses were found to be significant in the controls.”

“For the total sample, ACTH and cortisol significantly increased after naltrexone compared with placebo (p < .05).”

“ NTX increased ACTH levels in alcohol drinking females in diestrus, but not in other groups.”

“ Naltrexone , 0.1-1.0 mg/kg, increased ACTH levels, whereas naltrindole and clocinnamox failed to increase ACTH levels.”

“ Naltrexone also increased plasma concentrations of ACTH and corticosterone above basal levels at a later time in DALA-treated animals.”

“ Naltrexone increased the adrenocortical response to ACTH in DALA-treated rats.”

“Furthermore, naltrexone at a dose level that had no effect on motor activity blocked the suppressive effect of the high doses of ACTH but had no effect on the stimulating effect of the intermediate dose of ACTH.”