Possible Interaction: Naloxone and Oxytocin

“We conclude that opioid receptor blockade with naloxone has an inhibitory effect on the neural pathways mediating the oxytocin response at orgasm.”

“We discuss the potential benefit of concurrent administration of OT and naloxone (NAL) to robustly modulate social behavior.”

“In the presence of naloxone , plasma AVP and OT levels in response to nicotine were significantly higher than those in the control test.”

“Plasma OT concentrations rose significantly during ITT; the OT response was significantly reduced by the treatment with SRIH and increased in the presence of naloxone.”

“Antiallodynia induced by oxytocin (20 ng/site) was inhibited by prior intra-VLOC administration of atosiban (an oxytocin receptor antagonist, 100 ng/site) and naloxone (an opioid receptor antagonist, 500 ng/site).”

“ OT coadministered with a μ-opioid receptor antagonist, naloxone , invoked a supralinear enhancement of prolonged and selective social attention, producing a stronger effect than the summed effects of each administered separately.”

“Treatment with naloxone (an opioid antagonist) greatly enhanced the oxytocin response to IL‐1β in pregnancy, and finasteride did not enhance this effect, indicating that allopregnanolone and the endogenous opioid mechanisms do not act independently.”

“The results showed that (1) the concentrations of OXT, L-Ek, M-Ek and β-Ep, not DynA(1-13) in …) in the PAG perfusion liquid were decreased by the OXT receptor antagonist; (3) the increased pain threshold induced by the OXT … naloxone , an opiate receptor … exogenous OXT administration.”

“The opioid receptor antagonist, naloxone , increased oxytocin neuron post‐spike excitability in morphine‐dependent rats; this increase was greater for short interspike intervals (< 0.1 s).”

“SummaryStudies performed in conscious female rats confirmed that iv injection of cholecystokinin octapeptide (CCK; 20µ/kg) … circulating concentration of oxytocin but not that of vasopressin, and confirmed that the stimulation of oxytocin release was markedly facilitated … iv administration of naloxone (1mg/kg), indicating attenuation of … release by endogenous opioids.”