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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Naloxone
supplement:
Glutamic Acid
Research Papers that Mention the Interaction
“Replacement of TM II Asp114 with asparagine or glutamic acid increased mu receptor affinity for naloxone.”
-mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity.“Morphine effects on SR 141716A-induced penile erection, glutamic acid and NO(2)(-) increase were prevented by the prior administration of naloxone , an opioid receptor antagonist (5 microg) given into the paraventricular nucleus.”
Morphine reduces penile erection induced by the cannabinoid receptor antagonist SR 141617A in male rats: Role of paraventricular glutamic acid and nitric oxide“In rats, pretreated with naloxone , there was restoration as well as augmentation of morphine- induced antinociception in the presence of L- glutamic acid with an increase in TFL (9.0 ± 0.4 sec; P < 0.0001).”
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