Possible Interaction: Naloxone and Adrenocorticotropic Hormone

“Naloxone NAL ) has been reported to stimulate ACTH secretion indirectly through the release of endogenous hypothalamic CRH, suggesting its potential application in the examination of suprapituitary regulation of ACTH secretory dynamics.”

“Cortisol and ACTH showed a sharp and significant rise after naloxone treatment in both RA and normal subjects (P < 0.001 and P < 0.01), but no difference was observed between the two groups.”

“In humans, the opioid antagonist, naloxone , stimulates the release of CRH, and so of ACTH and cortisol, while alprazolam, an indirect GABAA agonist, blocks naloxone‐induced ACTH and cortisol secretion.”

“The increase in ACTH was enhanced following naloxone.”

“At rest plasma levels of adrenocorticotropin (ACTH), cortisol, and aldosterone increased during infusion of naloxone , while body temperature decreased.”

“In both species, naloxone , an opiate antagonist, stimulates the release of ACTH suggesting a tonic suppression by endogenous opioids.”

“It has been reported that the opiate antagonist, naloxone , is clinically useful in paradoxically inhibiting the release of ACTH in patients with Nelson's syndrome, but this requires adequate confirmation.”

“In abrupt withdrawals precipited by naloxone , the plasma adrenocorticotropin (ACTH) rises to a high level which can also be effectively suppressed by AES.”

“In the presence of naloxone , the ACTH and cortisol responses were significantly increased (maximum peak at time 20 min, P ≤ 0.02 vs. control test for ACTH, and at time 30 min (P ≤ 0.01 vs. baseline) for cortisol) whereas they were abolished by ALP.”

“Plasma concentrations of IBE, ACTH , and growth hormone increased significantly with NAL during high intensity exercise in the heat compared to SAL.”