Possible Interaction: Nafcillin and Trypsin

“On the basis of the experiments described, evidence is presented which indicates that subinhibitory levels of nafcillin produce an alteration of cell wall structure, thereby increasing permeability and rendering the cell wall and proto-plasmic constituents accessible to the action of lysozyme and trypsin.”

“Summary Studies on the effects of sub-inhibitory concentrations of nafcillin, oxacil-lin, and cloxacillin on S aureus supported the view that nafcillin and the isoxazole penicillins may induce important changes in the cell wall during growth that result in increased susceptibility to lysis by lysozyme and trypsin.”

“In addition, treatment with nafcillin rendered the normally lysozyme resistant cells of S. aureus susceptible to partial lysis by lysozyme and the concomitant addition of trypsin resulted in further dissolution of the cell bodies.”