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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Nadolol
supplement:
Sodium Cholate
Research Papers that Mention the Interaction
“The absorption of nadolol was, however, strongly inhibited by trihydroxy bile salts, sodium cholate and its taurine and glycine conjugates, but not by dihydroxy bile salts such as sodium chenodeoxycholate and sodium deoxycholate.”
“The results suggest a specific interaction between nadolol and trihydroxy bile salts, especially sodium cholate.”
Intestinal absorption of a beta-adrenergic blocking agent nadolol. I. Comparison of absorption behavior of nadolol with those of other beta-blocking agents in rats.“The hydrophilic cis-2, 3-diol moiety of nadolol plays an important role in stabilizing the micellar complex with sodium cholate.”
“The longitudinal relaxation times of the aromatic ring protons (C-4, C-6, C-7 and C-8) of nadolol were shortened by about 10% in the presence of sodium cholate , indicating that the aromatic ring protons were more immobilized upon complex formation.”
“These results suggest that the hydrophobic protons of sodium cholate and nadolol interact with each other, and complex formation with the hydrophobic protons inside and the hydrohilic protons outside may occur in aqueous solution.”
“It was found that the uptake of nadolol into the intestinal membrane was inhibited by sodium cholate and its conjugates, but the membrane permeability to nadolol was not affected.”
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