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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Nadolol
supplement:
Epigallocatechin Gallate
Research Papers that Mention the Interaction
“ EGCG competitively inhibited OATP1A2-mediated uptake of sulphobromophthalein and nadolol with Ki values of 21.6 and 19.4 μM, respectively.”
Role of (−)-epigallocatechin gallate in the pharmacokinetic interaction between nadolol and green tea in healthy volunteers“It has been reported that EGCG reduces plasma nadolol bioavailability in normotensive models.”
“Pre-treatment of EGCG resulted in a marked reduction of plasma nadolol maximum concentration (Cmax) and area under the time-plasma concentration curve (AUC) by 53% and 51% compared to its control.”
Oral epigallocatechin gallate reduces intestinal nadolol absorption via modulation of Oatp1a5 and Oct1 transcriptional levels in spontaneously hypertensive rats.“In addition, EGCG alone significantly reduced Cmax and AUC of nadolol.”
“These results suggest that the coadministration with green tea catechins , particularly EGCG, causes a significant alteration in the pharmacokinetics of nadolol , possibly through the inhibition of its intestinal absorption mediated by uptake transporters.”
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