Possible Interaction: NADH and Vitamin K

“Rotenone enhanced DL dose-dependently, whereas quercetin and menadione inhibited DL as well as NADH or FMNox.”

“However, only menadione and quercetin inhibited rat liver cytosol-mediated DHSA formation in the presence of NADH.”

“In addition, activity of plasma membrane electron transport, a system dependent in part on glycolytically-derived NADH , was also inhibited by menadione.”

“In the presence of KCN, NADH caused 34% and 12.5% reduction of the cytochromes aa3 and c, respectively, and negligible reduction of cytochrome b. Supplementation of the system with menadione rose the NADH-dependent reduction of all the cytochromes to levels that were close to the total content.”

“ Menadione promoted H2O2 production with either NADH or NADPH; paraquat was stimulatory only with NADPH.”

“These workers have shown that quinones of the menadione type are reduced to their quinol forms by the respiratory chain-linked NADH dehydrogenase in the presence of NADH.”

“Our results indicate that complexes I and II have resistance to their classic inhibitors, that the oxidation of NADH is stimulated by juglone, plumbagin and menadione , and that sensitivity to KCN is stimulated by the substrates TCHQ, NADH-DCPIP and NADH-TMPD.”

“Both enzymes have been shown to reduce both CB1954 and menadione in the presence of NADH and NADPH.”

“The rate of NADH oxidation increased with the amount of menaquinone incorporated in the vesicles up to saturation levels.”

“It was shown that the enzymatic reduction of menadione with the participation of either NADH or NADPH takes place by a "Ping-Pong" mechanism.”