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“In contrast, with the DTDP substrate, the activity was stimulated by retinol and the stimulations were in the part of the oscillatory pattern where retinol inhibition of NADH oxidation was observed.”
“The findings support an earlier proposed mechanism whereby retinol exerted opposing effects on NADH oxidation and protein disulfide reductions.”
“Also inhibited by retinol in these membrane preparations was their ability to oxidize NADH.”
“In the presence of NADH, retinol inhibited the protein disulfide-like activity over the same range of concentrations where retinol stimulated in the presence of reduced glutathione.”
“ NADH (0.5 mM) reduced retinoic acid synthesis from retinol , supported by NAD (2 mM), by 50-70%, but was fivefold less potent in reducing retinoic acid synthesis from retinal.”