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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: NADH and Triclosan



Research Papers that Mention the Interaction

Triclosan shows competitive kinetics with respect to NADH but is uncompetitive with respect to NAD(+), which shows that the binding of triclosan to the enzyme is facilitated in the presence of NAD(+).
Biochemical and biophysical research communications  •  2001  |  View Paper
Triclosan is an inhibitor of FabI and forms a stable ternary complex in the presence of NADH.
Acta crystallographica. Section F, Structural biology and crystallization communications  •  2011  |  View Paper
The results suggest that triclosan binds to E-NAD(+) complex, with a dissociation constant around 20-40 pM. Triclosan follows competitive kinetics with respect to NADH , giving an inhibition constant of 38 pM at zero NADH and saturating NAD(+).
Biochemistry  •  1999  |  View Paper