supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
NADH
drug:
Sevoflurane
Research Papers that Mention the Interaction
“NADH-stimulated oxidoreductase activity (25 μM NADH ; 0.8 mM NAD+) increased with sevoflurane.”
Sevoflurane modulates the activity of glyceraldehyde 3-phosphate dehydrogenase“Halothane, isoflurane and sevoflurane dose‐dependently inhibited NADH :DBQ oxidoreductase activity.”
“Unlike the classical inhibitor rotenone, none of the anaesthetics completely inhibited enzyme activity at high concentration, suggesting that these agents bind weakly to the ‘hydrophobic inhibitory site’ of complex I. In conclusion, halothane, isoflurane and sevoflurane inhibit complex I ( NADH :ubiquinone oxidoreductase) of the electron transport chain.”
Halothane, isoflurane and sevoflurane inhibit NADH: ubiquinone oxidoreductase (complex I) of cardiac mitochondria
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback