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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
NADH
drug:
Ranolazine
Research Papers that Mention the Interaction
“With broken …, ranolazine … NADH but not succinate oxidation and with pIC50 values in the lower range of 3-50 microM. Studies with different electron acceptors and respiratory … respiratory Complex I at a site between ferricyanide and menadione and ubiquinone-1 reduction (i.e. at a similar locus to rotenone).”
The antianginal agent ranolazine is a weak inhibitor of the respiratory complex I, but with greater potency in broken or uncoupled than in coupled mitochondria.
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