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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
NADH
drug:
Nitroprusside
Research Papers that Mention the Interaction
“The NADH and NADPH dependent microsomal reduction of nitroprusside results in the production of nitroprusside nitroxide radical, which in the presence of oxygen undergoes redox cycling to generate superoxide radical, and eventually hydroxyl radical is formed by a Fenton-type of reaction.”
Generation of reactive oxygen species by the redox cycling of nitroprusside.“A membrane fraction enriched in NADH oxidoreductase activity showed a NADH-dependent release of NO from nitroprusside; nitroprusside caused NADH consumption, and it also inhibited the NADH-dependent reduction of nitroblue tetrazolium.”
“In homogenates of … arteries, NADH (0.1 mmol/L) increased the release of NO from nitroprusside by approximately 6-fold, whereas NADPH, mitochondrial substrates, and other redox cofactors had minimal effects on NO release, and the action of NADH on nitroprusside was inhibited by nitroblue tetrazolium, ferricyanide, and diphenyliodonium.”
Potential role of a membrane-bound NADH oxidoreductase in nitric oxide release and arterial relaxation to nitroprusside.“Moreover, higher doses of nitroprusside resulted in a significant elevation in NADH levels that could be correlated to the decrease in blood pressure.”
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