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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In vitro studies demonstrated that nicotinamide increases NAD and NADH content of beta cells.”
Nicotinamide Effects Oxidative Burst Activity of Neutrophils in Patients with Poorly Controlled Type 2 Diabetes Mellitus“ Nicotinamide positively regulates glyceraldehyde-3-phosphate dehydrogenase when NADH is added.”
“Moreover, nicotinic acid inhibited de novo NAD+ synthesis through Hst1-mediated BNA repression, hindered the reuptake of extracellular QA, and thereby reduced de novo NAD+ synthesis.”
The copper-sensing transcription factor Mac1, the histone deacetylase Hst1, and nicotinic acid regulate de novo NAD+ biosynthesis in budding yeast“Liver total NAD, NAD(+) , and NADH levels were remarkably higher in the NA supplemented group than the NA deficient or EtOH alone groups.”
“Intraperitoneal injection of Nam, NAD+ and NADH produced significant increases in urinary excretion of Nam and its metabolites.”
“The activity of NADH :ferricyanide reaction of complex I was, however, reduced by administration not only of paraquat but also nicotinamide.”
“This local movement of a few residues in the loop is sufficient to trap the nicotinamide ring of NADH within the active-site area close to a productive binding position.”
“The decreased islet content of NADH plus NAD, which was observed after alloxan treatment, could be prevented by nicotinamide.”
“ NiAm injection elicited an increase in NAD+ (maximum change, 290%), a lesser increase in NADH (maximum change, +45%), but no change in the content of ATP or cyclic AMP in the renal cortex.”
“The inhibition of mitochondrial and microsomal DPNH oxidation by nicotinamide was noted during the course of these experiments.”
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