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Last Updated: 2 years ago

Possible Interaction: NADH and Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

Here we report that the oxidation of NADH by isolated plasma membrane vesicles was inhibited, as well, by adriamycin.
Journal of bioenergetics and biomembranes  •  1997  |  View Paper
Both NADH ferricyanide reductase and vanadate-stimulated NADH oxidation are inhibited by adriamycin , as is a cyanide insensitive ascorbate oxidase activity, whereas NADH cytochrome c reductase is not affected.
Biochemical and biophysical research communications  •  1980  |  View Paper
Doxorubicin (5-50 microM)-stimulated enzyme-catalyzed oxidation of NADH was also diminished, but still detectable, in the presence of chromatin.
In the presence of Fe(III), NADH dehydrogenase-catalyzed reduction of doxorubicin caused enhancement in the content of all modified bases over control levels.
NADH dehydrogenase-catalyzed reduction of doxorubicin (25-100 microM) caused hydroxyl radical production detected as methane generated from dimethyl sulfoxide; addition of isolated human chromatin to the system produced a concentration-dependent quenching of detectable hydroxyl radical formation.
Biochemistry  •  1992  |  View Paper
Both adriamycin and bathophenantroline disulfonate (BPS), previously reported as transplasma membrane electron transport inhibitors, also inhibit the CUP-stimulated NADH oxidation of pig liver plasma membranes.
Biochemical and biophysical research communications  •  1992  |  View Paper
Emodin, doxorubicin and organic extracts of C. obtusifolia inhibited NADH :cytochrome c oxidoreductase activity of bovine heart mitochondrial particles and NADH:CoQ oxidoreductase activity of porcine heart mitochondrial NADH dehydrogenase, whereas juglone was stimulatory.
Toxicon : official journal of the International Society on Toxinology  •  1989  |  View Paper
No significant effects were observed with guanine nucleotides or with neomycin, although NADH produced a modest increase and adriamycin a small inhibition of inositol phosphate production in permeabilized islets.
The Biochemical journal  •  1986  |  View Paper
Doxorubicin and daunorubicin inhibited the reduction of NAD+ to NADH during reverse electron transport.
The Journal of biological chemistry  •  1986  |  View Paper