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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
NADH
supplement:
Alpha-Ketoglutaric Acid
Research Papers that Mention the Interaction
“In fractions of rat liver cytosolic extracts that had been chromatographed on an anion exchanger we detected an enzyme reducing α-ketoglutarate in the presence of NADH.”
l-2-Hydroxyglutaric aciduria, a defect of metabolite repair“From the mini-review of research works published during the last 25 years, the following basic view is clear: a) animal KGDHC is …, NADH, and succinyl-CoA; d) the ATP effect is realized in several ways, probably mainly via opposition versus ADP activation; e) NADH, … α-ketoglutarate dehydrogenase … ADP.”
“The main alterations include (i) impaired BCAA transamination due to decreased supply of amino groups acceptors α-KG , pyruvate, and oxaloacetate) and (ii) inhibitory influence of NADH and acyl-CoAs produced in fatty acid oxidation on citric cycle and BCKA dehydrogenase.”
“In the presence of α-ketoglutarate and NADH , with K + replacing NH 4 + , the two chemically identical domains become conformationally different.”
The interaction of chlorpromazine and butyrophenones with glutamate dehydrogenase.“Kinetic data suggested that α-ketoglutarate was a partially competitive inhibitor with respect to both the substrates, NADH and oxaloacetate.”
Malic dehydrogenase isoenzymes in green stem tissue of Opuntia: isolation and characterization.“On the other hand, the substrates, NADH and α-ketoglutarate , at high levels, were strongly inhibitory, and the reciprocal plots for NADH oxidation were also nonlinear.”
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