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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
NADH
supplement:
Alpha-Ketoglutarate
Research Papers that Mention the Interaction
“ 2-Oxoglutarate and NADH , separately or together, gave partial but not complete protection against the inhibition.”
Effects of ADP on different inhibitory properties of brain glutamate dehydrogenase isoproteins by perphenazine.“ NADH inhibits OGDC versus both 2-oxoglutarate and NAD+.”
“The rate constant for reaction of GMPSBOP with the enzyme exhibits a nonlinear dependence on reagent concentration with KD = 75 microM. The …-ketoglutarate, GTP, ADP, or NADH alone results in little decrease in the rate constant, but the combined addition of 5 mM NADH with … mM alpha-ketoglutarate reduces ….”
“The effects of GTP and 2-oxoglutarate in potentiating inhibition by NADH can account for their effects in enhancing the apparent activation by L-leucine.”
“The presence of high concentrations of NADH (200 microM) potentiated the high substrate inhibition by 2-oxoglutarate , and L-leucine significantly reduced this effect.”
“NAD+, oxalacetate, citrate, ATP, and L(-)- or D(+)-malate had no effect on the association of the two enzymes, whereas alpha-ketoglutarate increased and NADH decreased it.”
“The oxidized coenzymes were shown to activate alpha-ketoglutarate amination at inhibiting concentrations of NADH and NADPH.”
“It was demonstrated that NADH inhibits both the lipoamide dehydrogenase and the oxoglutarate dehydrogenase components of the bovine adrenal complex.”
“ NADH increases the region of 2-oxoglutarate concentrations, in which the signs of cooperative binding of the substrate are observed in the absence of phosphate ions.”
“When the NADH content of hepatocytes was increased by 3-hydroxybutyrate, the addition of NH4Cl and/… alpha-methylisocitrate caused a decline in NADH (and NADPH) content, suggesting that reducing equivalents from NADH as well as from NADPH … support net reductive amination of 2-oxoglutarate when required for urea synthesis.”
“ NADH , especially in the presence of 2-oxoglutarate , protects the enzyme against tryptic degradation.”
“Isocitrate dehydrogenase, the novel biotin protein, ATP‐Mg and NADH were essential for the reductive carboxylation of 2‐oxoglutarate.”
A novel biotin protein required for reductive carboxylation of 2‐oxoglutarate by isocitrate dehydrogenase in Hydrogenobacter thermophilus TK‐6
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