Possible Interaction: NAD and Vitamin C

“Preclinical studies show that high-dose vitamin C can prevent or restore microcirculatory flow impairment by inhibiting activation of nicotinamide adenine dinucleotide phosphate-oxidase and inducible nitric oxide synthase, augmenting tetrahydrobiopterin, preventing uncoupling of oxidative phosphorylation, and decreasing the formation of superoxide and peroxynitrite, and by directly scavenging superoxide.”

“In general, VC treatment led to inhibition of energy metabolism via NAD+ depletion and amino-acid deprivation.”

“Collectively, our data suggests that vitamin C inhibited energy metabolism through NAD depletion, thereby inducing cancer cell death.”

“The authors speculate on a range of possible mechanisms by which vitamin C may improve contractile function, in particular, by a reduction in reactive oxygen species (ROS) from mitochondrial nicotinamide adenine dinucleotide phosphate-oxidase sources.”

“The coenzymatic capacity of NAD+ decreases by exposing it to the action of ascorbic acid --Cu(II) system, a generator of free radicals.”