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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: NAD and Tiazofurin

supplement:

NAD

Research Papers that Mention the Interaction

The NAD analogs of tiazofurin and selenazofurin were inhibitors of L1210 IMP dehydrogenase (IMP:NAD oxidoreductase, EC 1.2.1.14), and both showed uncompetitive inhibition with respect to NAD having Kii values of 5.7 X 10(-8)M and 3.3 X 10(-8)M respectively.
Biochemical pharmacology  •  1985  |  View Paper
These studies provide a basis for designing chemotherapy combinations in which tiazofurin or selenazofurin are used to modulate NAD and poly(ADP-ribose) metabolism to synergistically potentiate the effects of DNA strand-disrupting agents.
The Journal of clinical investigation  •  1985  |  View Paper