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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
NAD
drug:
Temozolomide
Research Papers that Mention the Interaction
“We therefore hypothesized that a strategy combining NAD+ biosynthesis inhibitors with the alkylating chemotherapeutic agent temozolomide could potentiate NAD+ depletion-mediated cytotoxicity in mutant IDH1 cancer cells.”
The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1-Mutant Cancers and Potentiates NAD+ Depletion-Mediated Cytotoxicity.“ TM and MNNG treatment decreased NAD levels in both cell lines, but took longer to return to control levels in TZR cells.”
Low nicotinamide mononucleotide adenylyltransferase activity in a tiazofurin-resistant cell line: effects on NAD metabolism and DNA repair.“ Temozolomide treatment caused a decrease in cellular NAD levels, and this was abolished by the PADPRP inhibitors.”
“The following parameters were assessed: their ability to inhibit the enzyme in permeabilised L1210 cells; their ability to potentiate the cytotoxicity of temozolomide (including the cytotoxicity of the compounds per se); their ability to increase net levels of temozolomide-induced DNA strand breaks and inhibit temozolomide-induced NAD depletion.”
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