Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: NAD and Tamoxifen

supplement:

NAD

Research Papers that Mention the Interaction

Surprisingly, tamoxifen , an estrogen receptor antagonist used for breast cancer treatment, increased the activity and decreased the Km for NAD+ by about twofold in ALDH1A1.
Proteins  •  2015  |  View Paper
The concentration of NAD in E2+ Tam 500 uteri was also significantly higher than E2 treated uteri.
The concentration of NAD in Tam 500 treated group was significantly higher than E2, low dose Tam and E2 + Tam 500 treated groups (P < 0.01).
Indian journal of experimental biology  •  1993  |  View Paper
Importantly, treatment with ER β agonist DPN (5 nM) significantly decreased the inhibitory effect of a PTEN knockdown on tamoxifen response of both cell lines (p<0.05).
Steroids  •  2020  |  View Paper