Possible Interaction: NAD and Streptozocin

“ Streptozotocin reduces NAD pools in HeLa cells; a concomitant stimulation of nuclear poly ADP(ribose) polymerase activity is noted.”

“ Streptozotocin , which induces diabetes mellitus in experimental animals, has been reported to be taken up by beta-cells by means of the glucose transporter 2 (GLUT2) and then reduce the cellular level of NAD+ , leading to necrosis of the beta-cells.”

“Syntheses of NAD and total pyridine nucleotides from nicotinic acid were significantly elevated 3 days after streptozotocin-injection but only total pyridine nucleotide synthesis was significantly higher 7 days after streptozotocin.”

“Pre‐incubation of NG108‐15 cells for 6‐8 h with streptozotocin (2‐5 mM) reduced NAD+ levels by 40‐50%.”

“Islet NAD + NADH contents were decreased by 50% after exposure to 2.2 mM SZ , compared to the control islets on day 0.”

“ Streptozotocin reduced the NAD content of the liver.”

“The islet NADH + NAD content decreased drastically when exposed to SZ.”

“ Streptozotocin , which produces diabetes mellitus in experimental animals1–3, has been reported to reduce the level of NAD in pancreatic islets4,5 and to inhibit islet synthesis of proinsulin6.”

“The diabetogenic action of streptozotocin is thus thought to be through the lowering of the amount of 8-cell NAD.”

“It seems that streptozotocin interfers with NAD formation in the beta-cell.”