supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
Research Papers that Mention the Interaction
“Binding of sorbitol in the substrate-binding site results in interactions with Lys-294, Tyr-50, His-69, Glu-150, and NAD+ while WAY135 706 interacts with Ser-46, Lys-294 and Phe-59.”
Modelling studies on the binding of substrate and inhibitor to the active site of human sorbitol dehydrogenase.“Increase in NADH/NAD+ promotes increased oxidation of sorbitol to fructose by polyol dehydrogenase; potential normalization of this ratio by coadministration of pyruvate (which reoxidizes NADH to NAD+ via lactate dehydrogenases reaction) was investigated.”
Effect of pyruvate on lens myo-inositol transport and polyol formation in diabetic cataract.“Aldose reductase (AR; ALR2; EC 1.1.1.…), a key enzyme in the polyol pathway, catalyzes nicotinamide adenosine dinucleotide phosphate-dependent reduction of glucose to sorbitol , leading to excessive accumulation of intracellular reactive oxygen species (ROS) in various tissues of DM including the heart, vasculature, neurons, eyes, and kidneys.”
Aldose Reductase, Oxidative Stress, and Diabetic Mellitus“Oxidation of D-sorbitol to D-fructose and xylitol to D-xylulose predominated in the presence of NAD at the optimum pH of 9.5-10.0.”
“NADPH could partially substitute for NADH.Maximum rate of NAD reduction in the presence of sorbitol occurred in tris(hydroxymethyl)aminomethane-HCl buffer (pH 9), or in 2-amino-2-methyl-1,3-propanediol buffer (pH 9.5).”
“The assay method depends on the increase in light absorbance at 340 mμ when nicotinamide adenine dinucleotide (NAD) is reduced in the presence of either D-mannitol 1-phosphate or D-sorbitol 6-phosphate.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback