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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
NAD
drug:
Salicylic Acid
Research Papers that Mention the Interaction
“ Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with nicotinamide adenosine dinucleotide ( NAD ) and noncompetitively with UDPG.”
Studies on mechanism of action of salicylates. V. Effect of salicylic acid on enzymes involved in mucopolysaccharides synthesis.“Large-scale transcriptomic analyses indicated that NAD promoted the induction of various pathogen-related genes such as the salicylic acid (SA)-responsive defence marker PR1.”
Inducible NAD overproduction in Arabidopsis alters metabolic pools and gene expression correlated with increased salicylate content and resistance to Pst-AvrRpm1.“ Salicylate has also been shown to inhibit malate and isocitrate dehydrogenase activities in vitro and the inhibitions were reversed by either NAD or NADP2.”
“We have now shown that the addition of NAD will reverse the inhibitory action of salicylate on mitochondrial malate dehydrogenase after this inhibition has become established.”
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